Emergence of Dalit writing is a result of assertion of Dalits in all spheres of their life. In post-independence time, due to constitutional safeguards, access to education, Dalit anti-caste movements and social activism, Dalits developed their Dalit consciousness and started asserting and finding their rightful place in the mainstream of society. After attaining education, writing about their struggle in the form of personal writing has proved to be an empowering act for them, and, hence, it is a part of their social activism against the oppressive caste system. The personal account of their struggle against all odds displays their never-say-die spirit which keeps them going in their dif icult times. The paper aims at mapping Dr. Kishor Shantabai Kale’s struggle for making ends meet and pursuing his higher education in Medicine. The textual analysis of Dr. Kishor Shantabai Kale’s Autobiography, Against All Odds reveals his inspiring life-journey from being an illegitimate son of a tamasha dancer to becoming a proud Doctor. It indicates how hope and resilience, coupled with hard work could give a strong sense of selfhood and purpose for living a meaningful life no matter how unpleasant situations are around.