This paper aims to study the perception of end users i.e., the buyers/consumers who purchase over the counter medicines when they see the advertisement either on television or on any such platforms. When a particular consumer sees the advertisement them, he makes a purchase decision when it comes to buy such products or medicines at that time which factors effects on his purchase decision if the marketers can know those factors it can help them in redesigning and restructuring their marketing strategies. Design. Methodology, Approach -Both primary and secondary research methods were employed. Data was collected from 200 participants; questions were Likert scale based on the parameters of consumers changes in likes dislikes, their purchase intentions and the impact of promotion mix elements. In this study, the researcher had set some questions, which were asked, to the consumers to fill, which was then analyzed to know the actual impact. The respondents were from different parts of Pune, Maharashtra, India. It was observed that the influence of promotional mix elements on consumer’s changes, their purchase intention of over-the-counter drugs also changes significantly. Promotional mix elements -sales promotion, Internet Marketing, and Publicity are significantly related to the education of the consumers. Key words: